Séminaire IBIP
Les séminaires ont lieu sur le Campus Montpellier SupAgro/INRA de La Gaillarde (2, place P. Viala Montpellier)

Jeudi 16 septembre 2010
Amphi 208 (Cœur d’Ecole) à 13h30

How the plant protein Remorin stick to the raft of the plasma membrane. A new mode for membrane raft anchoring?

Sébastien Mongrand
Laboratoire de biogénèse membranaire, CNRS/Bordeaux 2

Remorins (REMs) are proteins of unknown function specific to vascular plants. We haveused imaging and biochemical approaches and in situ labeling to demonstrate that remorinclusters in sterol-rich patches, similar to lipid rafts, in the inner leaflet of the plasmamembrane (PM) and at plasmodesmata in vivo. We found that the C-terminus of REMshares properties with class I fusion proteins from vertebrate-infecting viruses to provide ahydrophobic anchor into the membrane. From a manipulation of remorin levels intransgenic tomato plants it appears that REM acts as a gatekeeper for cell-to-cellmovement of the virus. The localization of REM and the impact on virus macromoleculartrafficking identify lipid rafts as functional components in plasmodesmata.

Contact : Magali di Pietro

Contacts IBIP :
Sabine Zimmermann
Marc Lepetit
Christine Granier
Corinne Dasen
Chantal Baracco