Here, we present integrative Regulatory Network (iRegNet), a web application that analyzes the upstream regulatory network for user-queried genes of interest (GOIs) or regions of interest (ROIs) in the Arabidopsis genome. iRegNet covers the largest empirically proven DNA-binding profiles of Arabidopsis transcription factors (TFs) and non-TF proteins, and histone modifications obtained from all currently available Arabidopsis ChIP-seq and DAP-seq data. iRegNet not only catalogs upstream regulomes and epigenetic chromatin states for single-query gene/genomic region but also suggests significantly overrepresented upstream genetic regulators and epigenetic chromatin states of user-submitted multiple query genes/genomic regions. Furthermore, gene-to-gene coexpression index and protein–protein interaction information were also integrated into iRegNet for a more reliable identification of upstream regulators and realistic regulatory networks.
[ Article de Plant Physiol. ] [ iRegNet ]