Séminaire IBIP
Les séminaires ont lieu sur le Campus Montpellier SupAgro/INRA de La Gaillarde (2, place P. Viala Montpellier)

Jeudi 26 mars 206 à 14h, Amphi 208

Yvon Jaillais
RDP ENS-Lyon

Role of anionic lipids in the establishment, dynamics and function of membrane contact sites

Membrane contact sites are areas of close membrane apposition that favor exchanges of molecules between cellular compartments. They are established by the action of tethering proteins that bridges the two contacting membranes. Anionic lipids, which are minor lipids in membranes, are also key determinants of membrane tethering. At the same time, anionic lipids are being actively transported from one membrane to another at contact sites. Thus, membrane contact sites are key structures regulating the homeostasis of anionic lipids in the cells and anionic lipids feedback on the organization and dynamics of membrane contacts. In my talk, I will describe our work on the characterization of this feedback loop. I will notably show the importance of phosphatidylinositol 4-phosphate (PI4P) in the establishment of ER/PM contact sites. I will also describe how local and tissue-scale PI4P regulations impact membrane contact site dynamics and their functions in both intra- and intercellular communication.

Contact : Alexandre Martinière