Les séminaires ont lieu sur le Campus Montpellier SupAgro/INRA de La Gaillarde (2, place P. Viala Montpellier)
Jeudi 31 janvier 2019
Salle 108 (coeur d’école) à 14h
The role of autophagy in cellular quality control and phenotypic plasticity
(Gregor Mendel Institute of Molecular Plant Biology, Vienna Biocenter-Austria)
Autophagy is an evolutionary conserved recycling mechanism that plays important roles in stress tolerance and cellular reprogramming. One of the major challenges is to understand how autophagy contributes to cellular homeostasis in different cell types, and how this translates into overall organismal performance. Plants provide unique opportunities to tackle this question in depth. As sessile organisms, they heavily rely on quality control mechanisms for environmental adaptation. To tolerate environmental heterogeneity, they have evolved highly plastic body plans, which requires efficient resource allocation and cell state switching mechanisms. Functional tools to investigate distinct cell lineages in growing intact organisms are readily available. Also, ATG8 gene family has expanded, potentially allowing compartmentalization of the autophagy responses. To develop a comprehensive understanding of the autophagy responses in plants, we hypothesized that ATG8 gene family expansion drives functional diversification of the autophagy responses. To test this hypothesis, we performed affinity proteomics for different ATG8 isoforms and obtained biochemical evidence supporting functional specialization of ATG8s. ATG8 interactome data also revealed a new selective autophagy receptor that is highly conserved in metazoans and contributes to endoplasmic reticulum homeostasis during ER stress. Here, I will present our latest findings on the new selective autophagy receptor and tissue specific autophagy responses. I will also discuss our efforts to inducibly manipulate autophagy in different cell types to dissect tissue specific cell autonomous and non-cell autonomous autophagy responses in plants.
Yasin Dagdas, email@example.com , @PlantoPhagy
Contact : Hatem Rouached