Jeudi 03 décembre 2020 à 14h00
(ZOOM : connexion donnée ultérieurement)
(Plant Molecular and Cellular Biology and Integrative
Biology Laboratory USA)
Iron levels mediate root priming against pathogen attack
Iron is an essential nutrient to promote growth of all living organism. Upon infection the iron is a cornerstone for the host-pathogen interaction. On one hand, the pathogen scavenges iron to spread the infection and in the other hand, the host decreases iron availability to reduce pathogen virulence. Thus, for the host, external iron sensing is of particular importance to prevent the infection. While it has been well established that iron levels are tightly linked to immunity response, it remains unclear by which molecular mechanisms iron levels and defense pathways are regulated. Using Arabidopsis thaliana root as a model, we identified by genome wild association study a cell surface receptor kinase, STRUBELIG RECEPTOR KINASE 3 (SRF3), sitting at the nexus between iron homeostasis and immunity pathways. By large-scale transcriptome analysis, biochemistry and cell biology approaches, we showed that iron deficiency initiates the immune response in order to prevent root against pathogen attack in an SRF3-dependent manner. We proposed that SRF3 might be involved in sensing external iron levels to activate the innate immune response in order to prime root cells to an eventual pathogen attack.
Contact : Valentin Chaput Montagnac (firstname.lastname@example.org)