Séminaire IBIP

Jeudi 12 novembre 2020 à 14h


Marie Cécile Caillaud
(Interactions Plantes–Microorganismes et Santé Végétale, Sophia Antipolis)

Investigating how Phospholipid Composition Impacts Plant Cell Division Orientation

A crucial feature of cell division is how cells position their division plane. It has even more significance for walled organisms because their cells are embedded and cannot relocate. Correctly positioning the division plane is therefore of paramount importance in plants as it controls asymmetric cell division, tissue morphogenesis, and organ integrity. In addition, cytokinesis in plants and animals is regulated by completely different mechanisms, which highlights that plants have evolved unique solutions to correctly position their division plane during development.

The memory of the cell division plane is maintained throughout plant cell division by a landmark at the equatorial periphery of the cell. How master regulators of plant cell division orientation are localized in this critical yet enigmatic structure called “Cortical Division Zone” while others are excluded from it remains unknown. Recent evidence shows that membrane lipids such as phosphoinositides (PIPs) are important for cell division orientation in plants. Preliminary data suggest that the coordination of cell division orientation requires a spatial/temporal regulation of the PIP-pattering for the recruitment ―and thereby the function―of proteins in specific zones of the plasma membrane throughout plant cell division.

We are currently trying to understand:
1) How the PIP-patterning is organized at the plasma membrane?
2) What is the impact of local perturbation of the PIPs-patterning?
3) What are the upstream molecular components responsible for the distribution of the PIPs?

Contact : Alexandre Martiniere (alexandre.martiniere@cnrs.fr)