Les séminaires ont lieu sur le Campus Montpellier SupAgro/INRA de La Gaillarde (2, place P. Viala Montpellier)
Jeudi 29 novembre 2012
Contribution of epigenetic changes to phenotypic variations in plants
BPMP, équipe Intégration des fonctions nutritives dans la plante entière
DNA methylation is an epigenetic chromatin mark that can be, to some instance, faithfully transmitted across generations. Loss or gain of DNA methylation can impact gene expression, and because these epigenetic perturbations can be transmitted transgenerationally, they can lead to the formation of heritable epimutations, with phenotypic consequences. Although a few natural epimutations have been described in plants, the extent of their contribution to phenotypic variation, as well as their establishment, remain largely unknown. To address these issues, we use a population of epigenetic recombinant inbred lines (epiRILs), which were derived from a cross between a wild-type line and an isogenic ddm1 mutant line, an Arabidopsis mutant affected in the epigenetic control of repeat sequences. Using a combination of large-scale phenotyping experiments and epigenome and transcriptome analyses, we highlight the potential of epimutations in the Arabidopsis genome, as well as the molecular determinants of these epimutations.
Contact : Antoine Martin