General information

Title:PhD Fellowship in Epigenomic and Genomic Regulatory Circuits Inference (M/W)
Reference : UMR5004-CECABA-005
Workplace : MONTPELLIER
Date of publication : Monday, May 06, 2019
Scientific Responsible name : Antoine MARTIN (CR CNRS, BPMP Montpellier) & Sophie LEBRE (MCF UM, IMAG Montpellier)
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 October 2019
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly

Description of the thesis topic

A three-year PhD position is available in our groups to work on epigenomic and transcriptomic regulatory circuits in Arabidopsis. The PhD program, supported by an 80 PRIME CNRS project, will be performed in a multidisciplinary and collaborative research environment that brings together biologists, mathematicians and chemists. The aim of the project is to build regulatory circuits of the response to nutritional starvation in the Arabidopsis root, notably by integrating cell-type specific dynamic epigenomes and transcriptomes, and transcription factors/chromatin interaction data. The PhD candidate will be co-supervised by Antoine Martin (biologist) and Sophie Lebre (mathematician), and will acquire multidisciplinary expertise in epigenomics, genomics, computational biology, networks inference and genome statistical analysis.
The PhD candidate will have to generate multiple cell-type specific epigenomic and transcriptomic datasets from Arabidopsis roots under nutritional starvation. The PhD candidate will analyze these genomic datasets, and integrate them in optimized regulatory circuits, together with transcription factors/chromatin interaction data. Regulatory circuits will be used to infer new major regulatory modules and genes of the response to nutritional starvation in Arabidopsis.

Work Context

The PhD student will be in the heart of a multidisciplinary project gathering biologists, mathematicians and chemists. He/she will be supervised by Antoine MARTIN (CR CNRS at the Biochemistry and Plant Molecular Biology laboratory in Montpellier) and Sophie LEBRE (Assistant Professor at the Institute Alexander Grothendieck in Montpellier), and assigned at these 2 research units. BPMP and IMAG are internationally-recognized in their respective field, and mutually benefit from an excellent environment to develop systems biology approaches in plants.

Constraints and risks

The large majority of the work will be performed under computer screen.

All the applications that will not be registered via the CNRS job portal will not be studied.