Nitrogen (N) nutrition relies on root acquisition of mineral resources, as well as on symbiotic N2 fixation by soil bacteria in legume plants.

Both processes are regulated by systemic signaling pathways aiming to adjust N acquisition depending on plant N needs and assimilation capacities.

Similar effectors acting in systemic signaling pathways are shared between these two N nutrition modes, including hormones such as cytokinins and peptide hormones, as well as related NIN-like protein (NLP) transcription factors.

Recent advances highlighted that systemic signaling pathways linked to N fixation and acquisition are tightly related to phosphate systemic signaling.

Light and/or CO2 shoot environmental factors impact N systemic signaling, suggesting mechanisms allowing the integration of N and C signaling and metabolism.

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