A new genus Otorhinophila, is proposed to include four species, three of them new. The species are: Otorhinophila intrasola sp. n. (type species), intranasal, type host Perognathus artus, other hosts Perognathus baileyi, P. goldmani, P. intermedius, P. penicillatus, P. pernix and Liomys pictus, type locality, 8 miles SSE Alamos, Sonora, Mexico, range from northern Sinaloa to northwestern Sonora, Mexico; Otorhinophila sinaloae, sp. n., intranasal, type host Perognathus pernix, other hosts Perognathus artus and Liomys pictus, type locality, 55 miles N Mazatlan, Sinaloa, Mexico, range in central Sinaloa, Mexico; Otorhinophila parvisola sp. n., type host Onychomys torridus, other hosts Perognathus (3 species), Dipodomys meniami, Citellus tereticaudus, Neotoma albigula and N. lepida, type locality, 9 miles NW Guaymas, Sonora, Mexico, range from Guaymas, central Sonora, northward through southern Arizona, southern California and northeastern Baja California Norte, Mexico; Otorhinophila sola (Gould), hosts Perognathus penicillatus and Neotoma lepida, range from northeastern Baja California Norte northward to southeastern California and southern Nevada. The larval and nymphal stages of each species are described and figured, and keys are provided. The distributions of the four species are illustrated.